Mohamed K. Mahfouz


BIOCHEMICAL EFFECTS OF LONG DURATION OF SEDATION ON NEUROTRANSMITTERS, PROTEIN FRACTIONS AND IMMUNOGLOBULINS

Mohamed K. Mahfouz, El-Far, A. H., Hussein A. Abdel Maksoud

Abstract
The present study was planned to know the biochemical effect of the long period of sedation on neurotransmitters, protein fractions and immunoglobulins. For this aim thirty adult male albino rats were allotted into two groups, control group of 10 rats were injected with an equivalent volume of physiological saline and the remained 20 rats were utilized as experimental group, injected with a long period of sedation (midazolam)-12 weeks. After that period, some neurotransmitters (adrenaline, dopamine and histamine) and serum components (serotonin, cholinesterase, protein electrophoresis, IgG, IgM, IgE and IgA) were investigated. Our study revealed that, injection of midazolam for 12 weeks has no obvious changes in the investigated neurotransmitters, serum electrophoretic pattern and immunoglobulins except a significant increase in Cholinesterase enzyme activities at 3rd and 4th weeks of experiment.

Key words: Midazolam, Neurotransmitters, Protein Fractions, Immunoglobulins


EFECTELE BIOCHIMICE ALE SEDĂRII DE LUNGĂ DURATĂ ASUPRA NEUROTRANSMIŢĂTORILOR, FRACŢIILOR PROTEICE ŞI IMUNOGLUBULINELOR

Mohamed K. Mahfouz, El-Far, A. H., Hussein A. Abdel Maksoud

Rezumat
Actualul studiu a fost proiectat sa investigheze efectul pe termen lung al sedarii asupra neurotransmitatorilor, fractiunilor proteice si imunoglobulinelor. În acest scop, 30 de sobolani albinotici adulti au fost grupati în doua loturi: control – 10 sobolani care au primit tratament cu ser fiziologic si experimental - 20 sobolani ce au fost tratati pe perioada de 12 saptamâni cu sedativ (midazolam). Dupa aceasta perioada unii neurotransmitatori (adrenalina, dopamina, histamina) si parametri serici (serotonina, colinesteraza, electroforeza proteica, IgG, IgM, IgE si IgA) au fost investigati. Studiul a demonstrat ca tratamentul injectabil cu midazolam, pe durata a 12 saptamâni, nu a provocat schimbari marcante asupra neurotransmitatorilor investigati, asupra parametrilor serici la electroforeza si a imunoglobulinelor, cu exceptia unei cresteri semnificative a activitatii enzimei colinesteraza din saptamânile a 3-a si a 4-a de experiment

Cuvinte cheie: Midazolam, neurotransmitatori, fractiuni proteice, imunoglobuline