BIOCHEMICAL EFFECTS OF LONG DURATION OF SEDATION ON NEUROTRANSMITTERS, PROTEIN FRACTIONS AND IMMUNOGLOBULINS

Mohamed K. Mahfouz, El-Far, A. H., Hussein A. Abdel Maksoud

Abstract
The present study was planned to know the biochemical effect of the long period of sedation on neurotransmitters, protein fractions and immunoglobulins. For this aim thirty adult male albino rats were allotted into two groups, control group of 10 rats were injected with an equivalent volume of physiological saline and the remained 20 rats were utilized as experimental group, injected with a long period of sedation (midazolam)-12 weeks. After that period, some neurotransmitters (adrenaline, dopamine and histamine) and serum components (serotonin, cholinesterase, protein electrophoresis, IgG, IgM, IgE and IgA) were investigated. Our study revealed that, injection of midazolam for 12 weeks has no obvious changes in the investigated neurotransmitters, serum electrophoretic pattern and immunoglobulins except a significant increase in Cholinesterase enzyme activities at 3^rd and 4^th weeks of experiment.

Key words: Midazolam, Neurotransmitters, Protein Fractions, Immunoglobulins